Mosul is the only major city east of Euphrates built primarily of stone and brick. It includes an extensive use of marble, especially in columns, door and window frames. Specialized masonry techniques, like the carving on marble with bitumen filling, were introduced to the city from Damascus during the reign of Nur al-Din. Its buildings and monuments were partially built with re-used elements from Roman temples and early Christian churches. In approximately 850 BCE, King Assubanipal II of Assyria chose the city of Nimrud to establish his capital, where present day Mosul is located. Around 700 BCE, King Sennacherib made Nineveh the new capital of Assyria. Mosul later succeeded Nineveh as the Tigris bridgehead of the road that linked Syria and Anatolia with Persia. By the eighth century, Mosul had become the principal city of northern Mesopotamia. 

The city was an important trade center in the Abbasid era, because of its strategic position on the caravan route between India, Persia and the Mediterranean. In 1127, Mosul became the capital of the Zangid dynasty until 1224, when it was sacked by the newly prominent local Badr al-Din Lu'lu'. During Badr al-Din Lu'lu''s reign, the city reached its apogee, and was widely known for its textile and metalwork. The city is also recognized for its abundance of shrines, dedicated to religious figures like Jonah, St. Georges, and several Shi'ite Imams. A distinguishing feature of these shrines is the dome, which appears a simple, conical or pyramidal form from the outside, but reveal exquisite muqarnas ornamentation from the inside. These forms spread beyond shrines, and were adopted by many local churches. Several decorative patterns and techniques that formed in Mosul also spread into the greater Muslim world, including brick decoration, and marble mosaic work. 

In the thirteenth century, Mosul was nearly destroyed by Mongol invasion. It was not until 1534, when the Ottomans took control over Mosul, that the city was rebuilt, and transformed into the region's commercial and administrative center. Mosul declined after the opening of the Suez Canal, but was revived with the discovery and development of petroleum reserves in the area in the 1920s.

Sources:

al-Janabi, Tariq Jawad. Studies in Medieval Iraqi Architecture. Baghdad : Ministry of Culture and Information, State Organization of Antiquities and Heritage, 1982. 

Ettinghausen, Richard and Oleg Grabar. The Art and Architecture of Islam. New Haven : Yale University Press, 1994. 

Architecture of the Islamic World, Edited by George Michell. London : Thames and Hudson, 1978. 

Bosworth, Clifford Edmond. The New Islamic Dynasties. New York : Columbia University Press, 1996. 

 Al-Tabbaa, Yasser Ahmad. The Architectural Patronage of Nur al-Din, (1146-1174). New York : New York University, University Microfilms International, 1982.